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Hiroshi Takayanagi, M.D., Ph.D.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine
The University of Tokyo

I was born in 1965 and graduated from the Faculty of Medicine, University of Tokyo in 1990. I was initially trained as an orthopaedic surgeon and rheumatologist in the Department of Orthopaedic Surgery, University of Tokyo. I began my basic research career in 1996 and discovered that bone destruction in arthritis is attributable to the enhanced expression of osteoclast differentiation factor, RANKL, in 2000. I was awarded Ph.D in 2001 by University of Tokyo and became Assistant Professor at the Department of Immunology, University of Tokyo (Prof. Tada Taniguchi). I further studied the regulation of bone metabolism by the immune system by focusing on the control of osteoclast differentiation and revealed the role of immunomodulatory factors including interferons, NFATc1 and immunoglobulin-like receptors in the skeletal system. In 2003, I was promoted to Professor at Tokyo Medical and Dental University and continued to explore the interdisciplinary field, osteoimmunology. Since 2006, I have been organizing the international conference on osteoimmunology. In 2012, I was promoted to Professor, Department of Immunology, Graduate School fo Medicine and Faculty of Medicine, The University of Tokyo.

Major Publications
Takayanagi, H. et al. Nature 408, 600-5 (2000)
Takayanagi, H. et al. Nature 416, 744-9 (2002)
Takayanagi, H. et al. Dev Cell 3, 889-901 (2002)
Kim, S. et al. Genes Dev 17, 1979-91 (2003)
Koga, T. et al. Nature 428, 758-63 (2004)
Koga, T. et al. Nat Med 11, 880-5 (2005)
Sato, K. et al. Nat Med 12, 1410-6 (2006)
Takayanagi, H. Nat Rev Immunol 7, 292-304 (2007)
Asagiri, M. et al. Science 319, 624-7 (2008)
Shinohara, M. et al. Cell 132,794-806 (2008)
Takayanagi, H. Nat Rev Rheumatol 5(12), 667-76(2009)
Okamoto, K. et al. Nature 464, 1381-5(2010)
Nakashima, T. et al. Nat Med 17, 1231-4 (2011)
Negishi-Koga, T. et al. Nat Med 17, 1473-80 (2011)
Hayashi, M. et al. Nature 485(7396), 69-74 (2012)
Komatsu, N. et al. Nat Med 20, 62 - 8 (2014)
Negishi-Koga, T. et al. Nat Commun 6, 6637 (2015)
Takaba, H., et al. Cell 163, 975 - 987 (2015)
Guerrini, M. M. et al. Immunity 43, 1174 - 85 (2015)
Ono, T. et al. Nat Commun 7, 10928 (2016)
Terashima, A. et al. Immunity 44, 1434 - 43 (2016)
Nagashima, K. et al. Nat Immunol 18, 675 - 682 (2017)
Tsukasaki, M. et al. Nat Commun 9, 701 (2018)
Inoue, A. et al. Nat Immunol 19(11):1265-1276 (2018)
Tsukasaki, M., Takayanagi, H. Nat Rev Rheumatol 19(10):626-642 (2019)
Asano, T. et al. Nat Metab 1:868-875 (2019)

Academic and Professional Awards
1997.9 Young Investigator's Award, American Society of Bone and Mineral Research
2002.10 Young Investigator's Award, International Cytokine Society
2002.11 Amersham Biosciences and Science Prize for Young Scientists
2004.4 Novartis Japan Rheumatology Prize
2004.4 Japan College of Rheumatology Award
2004.10 Fuller Albright Award, The American Society for Bone and Mineral Research
2005.3 2005 Japan Society for the Promotion of Science Prize
2005.3 Japan Academy Medal, The Japan Academy
2005.4 The Young Scientists' Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
2005.12 NISTEP AWARD 2005, National Institute of Science and Technology Policy, Ministry of Education, Culture, Sports, Science and Technology
2006.11 2006 International Research Prize, Austrian Society for Bone and Mineral Research (AuSBMR) and Ludwig Boltzmann Institute of Osteology
2008.10 2008 Academic Award of the Mochida Memorial Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research
2009. 2 Inoue Prize for Science, Inoue Foundation for Science
2009. 7 JSBMR Distinguished Scientist Award
2011. 5 3rd Joint Meeting of the European Calcified Tissue Society & International Bone and Mineral Society 2011 IBMS-Bone Herbert A. Fleisch Award
2016.12 JSI Award, Japanese Society for Immunology
2019.3 Uehara Prize
2019.6 Japan Academy Prize

Social activity
Vice President, Asia Pacific League of Associations for Rheumatology (2004.11~2008.9)
Organizing Committee, International Conference on Osteoimmunology (2005.3~)
Councillor, The Japanese Society for Clinical Reumatology and Related Research (2005.11)
Ancillary Program Committee, American Society for Bone and Mineral Research (2006.9~2007.12)
Science Council of Japan cooperation member (2006.8~)
Councillor, Japan College of Rheumatology (2007.5~)
Member, American Society for Clinical Investigation (2008.4~)
Executive Board member, Japan College of Rheumatology (2013.4~)
Executive Board member, The Japanese Society for Bone and Mineral Research (2013.4~)
President, Japanese Society of Osteoimmunology (2014.10~)
Vice President, The Japanese Society of Inflammation and Regeneration (2016.4~)
Executive Board member, Japanese Society for Immunology(2016.12~)
Chairperson, The Finance Committee of Japanese Society for Immunology(2017.1~)

Ad Hoc Reviewing
Nature Medicine, Nature Immunology, Nature Cell Biology, Genes & Development, Development Cell, The Journal of Experimental Medicine,The EMBO Journal, Proceedings of the National Academy of Sciences of the United States of America, Arthritis & Rheumatism, European Journal of Immunology, Biochemical and Biophysical Research Communications, The Journal of Cell Biology, Journal of Clinical Investifation, Osteoarthritis and Cartilage